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Title:	Seminar
Begin:	10/14/2009 12:00 PM
End:	10/14/2009 1:00 PM
Description:	Causal Ideas in RCTs: Treatment-Related Side Effects Nicholas Jewell, Ph.D. Professor Division of Biostatistics School of Public Health University of California, Berkeley   Randomization has been long used in therapeutic and intervention trials to form the basis of causal inference regarding treatment effects. The Methods for Improving Reproductive Health in Africa (NIRA) trial, designed to examine the effects of the diaphragm and lubricant gel in reducing sexually transmitted infections, raised issues regarding the standard intention-to-treat analysis due to the role of a secondary intervention on condom use. A similar causal diagram arises in a very different situation involving blinded clinical trials with treatment-related side effects due to the potential for unmasking of treatment assignment. We motivate and discuss these issues based on a randomized, double-blind, placebo-controlled trial of pain medication for patients suffering from diabetic neuropathy.  Sponsor: James Dai, 206.667.6364 / jdai@scharp.org Contact:  Eric Woodruff, 206.667.4145 / ewoodruf@fhcrc.org
Location:	FHCRC, Arnold Building, M1-A305/307
Recurrence:
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Created at 10/14/2009 11:12 AM by Sorenson, Lauri M Last modified at 10/14/2009 11:12 AM by Sorenson, Lauri M