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Title:	2009 Breslow Lecture UW Department of Biostatistics
Begin:	11/5/2009 3:30 PM
End:
Description:	Encountering the Generalized Linear Model in the Minefields of Epidemiology Presented by Clarice R. Weinberg, Ph.D. Chief, Biostatistics Branch National Institute of Environmental Health Sciences National Institutes of Health The generalized linear model (GLM) permits some odd and useful applications in epidemiology.  Three examples will be discussed.  In the first, using time‐to‐pregnancy data from couples attempting to conceive, one can apply GLMs to characterize the heterogeneous underlying fecundability distribution of couples in the population and identify exposures with effects on fertility.  In the second, expensive assays for exposure biomarkers can restrict the sample that can affordably be studied in a case‐control design.  By pooling biospecimens prior to assay, we can achieve more efficient use of both the biospecimens and the budget.  An extension of the same approach can improve efficiency in discrete-time survival models with a common outcome, e.g. time‐to‐pregnancy. The third example concerns the role of genetics and  environmental factors in a “complex” young‐onset condition, e.g. a birth defect.  With a log‐linear model that treats the family as the unit of analysis, one can study cases and their parents and assess both genotype relative risks and multiplicative gene‐by‐environment interaction.   Refreshments served outside the room from 2:30-3:30 pm   The University of Washington is committed to providing access, equal opportunity and reasonable accommodation in its services, programs, activities, education and employment for individuals with disabilities. To request disability accommodation contact the Disability Services Office at least ten days in advance at: 206‐543‐6450/V, 206‐543‐6452/TTY, 206‐685‐7264 (FAX), or dso@u.washington.edu.
Location:	Room T-747, Health Sciences University of Washington
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Created at 10/13/2009 10:06 AM by Sorenson, Lauri M Last modified at 10/13/2009 10:06 AM by Sorenson, Lauri M